Mattheos A.G. Koffas Associate Professor 904 Furnas Hall (716) 645-2911 ext. 2221 Fax: (716) 645-3822 mkoffas@buffalo.edu

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Research

Publications

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Chapters in Books

• Fowler, Z., Leonard, E, Koffas, M.A.G., "Biosynthesis of essential building blocks," In Metabolic Engineering, C. Smolke (Ed.), CRC Press (2007) [In Press].

• Fowler, Z., Koffas, M.A.G., "Microbial biosynthesis of fine chemicals," In Metabolic Engineering, C. Smolke (Ed.), CRC Press (2007) [In Press].

• Chemler, J., Leonard, E., Koffas, M.A.G., "Flavonoid biotransformations in microorganisms," In Anthocyanins: Biosynthesis, Function and Application, K. Gould, K. Davies and C. Winefield (Ed.), Springer (2007) [In Press].

 

Refereed Journal Publications

• Leonard, E., Lim, K.-H., Shaw, P.-N., Koffas, M.A.G., "Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli," Applied and Environmental Microbiology, April 27, 2007 [Epub ahead of print].

• Chemler, J., Yan, Y., Leonard, E., Koffas, M.A.G., "Combinatorial mutasynthesis of flavonoid analogues from acrylic acis in microorganisms," Organic Letters, May 10; 9(10), 1855-58 (2007).

• Chemler, J., Yan, Y., Koffas, M.A.G., "Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae," Microbial Cell Factories, 5(20), (2007).

• Leonard, E., Yan, Y., Koffas, M.A.G., "Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli," Metabolic Engineering, 8(20), 172-181, (2006).

• Leonard, E., Chemler, J., Lim, K.H., Koffas, M.A.G., "Expression of a soluble flavone synthase allows the biosynthesis of phytoestrogen derivatives in Escherichia coli," Applied Microbiology and Biotechnology, 70(1), 85-91, (2006).

• Leonard, E., Yan, Y., Lim, K.H., Koffas, M.A.G., "Investigation of two distinct flavone synthases for plant-specific flavone biosynthesis in Saccharomyces cerevisiae," Applied and Environmental Microbiology, 71(12), 8241-8248, (2005).

• Yan, Y., Kohli, A., Koffas, M.A.G., "Biosynthesis of natural flavanones in Saccharomyces cerevisiae," Applied and Environmental Microbiology, 71(9), 5610-5613, (2005).

• Yan, Y., Chemler, J. Huang, L., Martens, S., Koffas, M.A., "Metabolic engineering of anthocyanin biosynthesis in Escherichia coli," Applied and Environmental Microbiology, 71(7), 3617-3623, (2005).

• Koffas, M.A. and DelCardayre, S., "Evolutionary metabolic engineering," Metabolic Engineering, 7(1), 1-3, (2005).

• Koffas, M.A., Stephanopoulos, G., "Strain improvement by metabolic engineering:  Lysine production as a case study for systems biology," Current Opinion in Biotechnology, 16(3), 361-366, (2005).

• Koffas, M.A.G., Jung, G.Y. and Stephanopoulos, G., "Engineering metabolism and product formation in Corynebacterium glutamicum by coordinated gene overexpression," Metabolic Engineering, 5(1), 32-41, (2003).

• Koffas, M.A.G., Jung, G.Y., Aon, J.C. and stephanopoulos, G., "Effect of pyruvate carboxylase overexpression on the physiology of Corynebacterium glutamicum," Applied and Environmental Microbiology, 68(11), 5422-5428, (2002).

• Koffas, M.A.G., Roberge, C.M., Lee, K., and Stephanopoulos, G., "Metabolic Engineering," Annual Review of Biomedical Engineering, 1, 535-557, (1999).

• Koffas, M.A.G., Ramamoorthi, R., Pine, W.A., Sinskey, A.J., and Stephanopoulos, G., "Sequence of the Corynebacterium glutamicum pyruvate carboxylase gene," Applied Microbiology and Biotechnology, 50(3), 346-352, (1998).

 

Last Updated: October 2007